Lollipop Chainsaw is a video game featuring the main protagonist, Juliet Starling (voiced by Tara Strong). Juliet is a blonde haired senior at San Romero High School, where she is the head cheerleader. One fateful day, zombies invade the school grounds and Juliet's boyfriend, Nick is bit on the hand as Juliet mows down zombies with her chainsaw. Juliet's family are zombie hunters, which include her sisters Cordelia and Rosalyn, and her father. Nick is beheaded by Juliet and spends the majority of the video game as a talking animated head, thanks to a ritual Juliet performs to save Nick. Juliet and Nick team up with Cordelia, Rosalyn, Juliet's sensei, and the father to stop the undead.
Throughout the game, Juliet is given upgrades for her weapon by her family members for her birthday (which coincides with the zombie infestation) to help her fight the zombie bosses. The main antagonist has brought the undead plague from Rotten World, as well as the mini-bosses Juliet must defeat. The undead mini-bosses include a female undead hippie, a disco-loving zombie, a Viking, and a zombie rocker on a motorcycle. The final boss looks like a very fat undead Elvis Presley, called Rockabilly.
The name of the school where Nick and Juliet attend is a shout out to George Romero, the classic zombie horror producer.