Experiences with Using Transformations in PnP Campaigns

Would anyone care to share their experiences with various Transformations in traditional campaigns in Pen and Paper Roleplaying Games? I've only been GMing for a little over a year, and my group hasn't played all that long together (a little over my little over a year of GMing).
I think it would be a fun plot in general, but I'd need to go about it carefully. So I was wondering if anyone would be willing to share their experiences on the subject, particularly if the game they were in wasn't based around Transformation of one sort or another.
I think it would be a fun plot in general, but I'd need to go about it carefully. So I was wondering if anyone would be willing to share their experiences on the subject, particularly if the game they were in wasn't based around Transformation of one sort or another.